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Anti-NFKB p65 Monoclonal Antibody

產品簡介：

Anti-NFKB p65 Monoclonal Antibody
應用 WB IHC IP
稀釋比例WB 1:1000-3000. IP 1:100-300. IF 1:100-200. IHC 1:200-500.
交叉反應 Human Mouse Rat

產品型號：K200045M

更新時間：2022-08-15

廠商性質：生產廠家

訪問量：1358

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PRODUCT CLASSIFICATION

產品介紹

Anti-NFKB p65 Monoclonal Antibody

英文名稱	Anti-NFKB p65 Monoclonal Antibody
宿主	Mouse
別名	MGC131774;NFKB 3;NFKB3;TF65_HUMAN
應用	WB IHC IP
稀釋比例	WB 1:1000-3000. IP 1:100-300. IF 1:100-200. IHC 1:200-500.
蛋白分子量	65kDa
Gene ID	5970
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG1
免疫原	recombinant protein
性狀	液體
Public Immunogen Range	recombinant protein
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q04206
克隆號	5G6
克隆類型	Monoclonal Antibody
背景資料	NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.